Semi-desert grassland sector “Cîşliţa-Prut” (area of 42.8 ha) is located near the Prut riverbed and Prut village (d. Cahul). It is located on the sunny, west-facing slopes of complex meanders of the lower Prut River. The angle of inclination of the slope is 25-40 °, the inclination changes very quickly in places with steeps. Field research was conducted during 2007-2015 growing season according to the phytocoenological method and route surveys. Floristic research was conducted during the growing season (March-September). Phytosociological surveys were conducted according to the classical methodology of the Zürich-Montpellier school (Braun-Blanquet, 1964). Semi-desert steppes are formed at the transition from the desert steppe and are characterized by alteration of perennial herbaceous plant communities, xerophyte, with rich plant communities of semi-shrubs, xerophytic unfinished (Postolache 1994, 1995). A phase of semirest during the long summer is characteristic of semi-desert steppe plant communities (Keller, 1923). These and other features of the semi-desert grassland area “Cîşliţa-Prut” were recorded. In the sector “Cîşliţa-Prut”, there were 237 species of vascular plants. The spectrum of the bioforms: the therophytes are clearly dominant 41.1%, followed by hemicryptophytes 40%, geophytes 9.2%, fanerophytes 6.7% and chamaephytes 3.3%. The analysis of the phytogeographic elements: Eurasian element 45.1% and pontic species 28.2%, followed by the European 7.6%, Central-European 5.9%, Mediterranean 3.7%, adventive and circumpolar with 2.5% each, cosmopolite 2.1%, Submediterranean 1.2%, Atlantic and Pannonian with 0.4% each. The analysis of the ecologic spectra: the xerophytes 65%, xeromesophytic species 33.3% and amphitolerant 1.6%. The economical plant importance. Analyses of plants from wild flora are represented by relevant categories of economical importance of plants. The most numerous are the medicinal 41.1%, melliferous and industrial 19.1%, fodder 9.3%, alimentary 6%, decorative 3.5% and toxic plants 1.9%. Rare plants. In the steppe “Cîşliţa-Prut”, 30 species of vascular plants with varying degrees of rarity were identified. In accordance with the Law on Natural Areas Protected by the State (1998) and International Union for Conservation of Nature (IUCN, 1994), these species are grouped into the following categories of rarity; the plants included in the Red Book of Moldova (RBM, second edition, 2001) belong to 6 species. Plant communities of the “Cîşliţa-Prut” were assigned to nine associations. In the semi-desert grassland sector “Cîşliţa-Prut”, were found 30 species of rare plants, including 6 species of rare plants (Astragalus dasyanthus, Colchium triphyllum, Convolvulus lineatus, Ephedra distachya, Gypsophila glomerata, Ornithogalum amphibolum) that are included in the Red Book of Moldova. Given the presence of rich gene pool (237 species of vascular plants), of which 30 rare plant species, plant communities assigned to the nine associations, it was proposed to establish the semi-desert grassland steppe “Cîşliţa-Prut” with surface 42.8 ha of meadow as protected area named “Cîşliţa-Prut”.