Ultrasounds has a wide range of active applications spreading in solid, liquid and gaseous mediums, like: cleaning, degassing, quality control, sonochemistry disintegration, accelerate and optimize the machining, diffusion and electrochemical processes, embedded in new methods and technologies for preventing, reducing and removing of existing pollution. The wastewater sonochemical treatment is used for numerous pollutants usually in combination with other methods of treatment. There are presented main type of sonochemical technologies applicable to wastewater treatment reviewed in the scientific literature: gas bubbling installation, UV hybrid or sono-electro-chemical systems, installation with specific configurations and large-scale sonochemical reactors. The authors show some examples of pollutants destructed using ultrasound irradiation. Them work covers the wastewater sonochemical treatment of waters with organochlorine substances and cyanides content. The purpose of authors is to find the optimum work parameters and the most convenient technical configurations for the experimental installations.