The old pesticide storages have a relative high pollution level and should to be remediated for the reduction of the hazard and risks for the environment and public health. Several projects were made for the testing of in-situ remediation technologies like bio- and phytoremediation. The aim of this article is a review of remediation technologies which can be used in the conditions of Republic of Moldova. The POPs degradation and microbiological properties of contaminated soils have been investigated in the application of the phytoremediation experiment and DARAMEND technology. The activation of soil microorganisms in the complex with “Green Chemistry” approach leads to the destruction of POPs in soil and decreasing of hazards from high polluted soil. Indices of the microbial biomass, counts of culturable microorganisms (heterotrophic bacteria, actinomycetes and fungi) and dehydrogenase activity have been determined by these experiments. The result is that POPs degradation after phytoremediation was significant and coincided with the growth of the microbiological activity. The utilization of DARAMEND in most cases promotes the growth of microorganisms. In the same time POPs degradation in soil without DARAMEND was also significant. Activated carbon was obtained from local raw materials and was used for the remediation of POPs polluted soil in laboratory conditions. Results showed a good perspective for the utilization of this material for the soil detoxication and soil remediation. The experience of the site remediation in the Republic of Moldova showed that local conditions should to be determined individually for every site. Another major factor for the remediation action is pollution spectrum. The conclusion is that possible remediation action should to be developed after the complex study of pollution spectrum and geotechnical conditions for every polluted site by the complex approach.