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SM ISO690:2012 KRESYUN, Nataliya, GODOVAN, Valentina, SON, Hanna, GODLEVSKA, Tamara. Effects of niacin-oxyethylidendiphosphonato-germanate and alpha-lipoic acid upon diabet-induced oxidative stress in retina. In: Sănătate Publică, Economie şi Management în Medicină , 2018, nr. 4(78), pp. 52-57. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 4(78) / 2018 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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CZU: 615.252.349.7:612.015.11+617.735-002:616.379-008.64-092.9 | ||||||
Pag. 52-57 | ||||||
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Effects of two weeks treatment with niacin-oxyethylidendiphosphonatogermanate (MIGU-4, 2,5; 25,0 mg/kg, i.p.) and alpha-lipoic acid (LA, 5,0 and 50,0 mg/kg, i.p.) as well as their combined usage (MIGU-4 – 2,5, and LA – 5,0 mg/kg) upon antioxidative enzymes and level of malon dialdehyde (MDA) in retina tissue of rats with streptozotocin (STZ)induced diabetes was determined. It was established that in six weeks after STZ administration superoxiddismutase (SOD) activity decreased by 33,4% (P<0,05), catalase (CAT) – by 28,2% (P<0,05), glutathione peroxidase (GPx) – by 39,8%, glutathione reductase (GR) – by 48,3%, and MDA level raised by 2,65 times when compared with intact rats (P<0,05). MIGU-4 treatment (25,0 mg/kg, i.p.) increased SOD activity by 38,1% (P<0,05), GPx and GR – by 62,9% (P<0,05) and by 35,2% (P<0,05), when compared with diabetes rats. MDA level was reduced by 30,2% (P<0,05) correspondently. The SOD activity under condition of combined MIGU-4 (2,5 mg/ kg) and LA (5,0 mg/kg) administration exceeded its level in rats with diabetes by 41,3% (P<0,05), while activity of GPx and GR also was higher by 52,4% and by 47,8% (P<0,05) correspondently. MDA level reduction was higher than in groups which were given MIGU-4 or LA alone (P<0,05). Thus, niacin-oxyethylidendiphosphonato-germanate caused prevention on diabetes-induced deterioration of antioxidant enzymes activity and level of MDA in retina tissue. Combined usage of MIGU-4 and LA was resulted in heightened preventive effects upon manifestations of oxidative stress. |
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Cuvinte-cheie diabet experimental, stres oxidativ, streptozotocin, retinopatie diabetică, niacin-oxietildendifosfonat germanat, acid lipoic |
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