Introducere. Organizaţia Mondială a Sănătăţii referă migrena printre cele 20 de maladii, iar la femei printre cele 10, cu grad înalt de invalidizare şi care dereglează capacitatea de muncă. Scopul lucrării. Analiza literaturii şi caracterizarea preparatelor şi formelor medicamentoase noi utilizate pentru jugularea acceselor de migrenă. Material şi metode. S-a efectuat studiul literaturii de specialitate, inclusiv a ghidurilor asociaţiilor internaţionale de neurologie, de studiu a cefaleei, în vederea elucidării noilor grupe de preparate utile pentru jugularea acceselor de migrenă. Rezultate. Pentru jugularea acceselor de migrenă cele mai accesibile şi utilizate sunt preparatele nonspecifice (analgezicele neopioide, antiinflamatoarele nesteroidiene, antiemeticele, preparatele combinate) şi specifice (triptanii, alcaloizii din ergot, preparatele combinate). Datele de patogeneză au permis de a propune pentru jugulartea acceselor de migrenă unele clase noi de medicamente: agoniştii selectivi ai 5HT1F-receptorilor, inhibitorii NO-sintazei; anticorpii monoclonali şi antagoniştii peptidei similare genei calcitoninei; antagoniştii glutamatergici; preparatele toxinei botulinice A; preparatele magneziului. Concomitent, au fost studiate un şir de forme medicamentoase noi: aerosoli nazali (sumatriptan, zolmitriptan, dihidroergotamina, ketorolac etc.); emplastre (sumatriptan), dispozitive pentru introducerea subcutanată (sumatriptan), comprimate orale dispersabile (rizatriptan, zolmitriptan, diclofenac de potasiu, acid acetilsalicilic, nurofen expres forte), supozitoare (paracetamol, sumatriptan, acid acetilsalicilic). Concluzii. Preparate de I linie pentru jugularea acceselor de migrenă (formele uşoare şi medii) au rămas analgezicele neopioide, antiinflamatoarele nesteroidiene şi preparatele combinate. Triptanii se consideră medicamente de linia a II (formele medii), iar alcaloizii din ergot şi preparatele combinate (triptani, alcaloizi din ergot cu analgezice şi antiinflamatoare nesteroidiene) – de linia III (formele grave).

Introduction. Migraine is classified by World Health Organization among those 20 diseases, but in women among those 10, with a high degree of disability which disturb the work capacity. Objective of the study. Analisis of the literature and the characterisation of new drugs and forms used for jugulating migraine accesses. Material and methods. A study of the specialty literature was performed, including the guidelines of international neurology associations, for the study of headache, in order to elucidate the new groups of useful preparations for the jugulating of migraine attack. Results. The most suitable and used preparations for migraine attack are the non-specific preparations (non-opioid analgesics, non-steroidal anti-inflammatory drugs, anti-emetics, combined preparations) and specific (triptans, ergot alkaloids, combined preparations) for migraine attacks jugulation. Pathogenesis data allowed to propose some new drug classes for migraine attack jugulation: 5HT1freceptor selective agonists, NO-synthase inhibitors; the monoclonal antibodies and calcitonin gene similar peptide antagonists; glutamatergic antagonists; botulinum toxin A preparations; magnesium preparations. Concomitantly a huge number of new drug forms have been studied: nasal aerosols (sumatriptan, zolmitriptan, dihydroergotamine, ketorolac etc.); emplasters (sumatriptan), oral dispersible tablets (rizatriptan, zolmitriptan, potassium diclofenac, acetylsalicylic acid, express forte nurofen), suppositories (paracetamol, sumatriptan, acetylsalicylic acid). Conclusions. Ist line preparations for migraine attack jugulation (mild and medium forms) remained neopioid analgesics, non-steroidal anti-inflammatory drugs and combined preparations. Triptans are considered to be the IInd line drugs (medium forms), but ergot alkaloids and combination preparations (triptans, ergor alkaloids with analgesics and non-steroidal anti-inflammatory drugs) – IIIrd line (severe forms).