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Ultima descărcare din IBN: 2020-05-05 03:30 |
SM ISO690:2012 BABENCO, Elena. Significance of Brain Natriuretic Peptide among Patients with Cardiac Dysfunction and in Pregnancy
. In: Curierul Medical, 2011, nr. 4(322), pp. 52-55. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 4(322) / 2011 / ISSN 1875-0666 | ||||||
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Pag. 52-55 | ||||||
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The cardiac natriuretic peptides or the natriuretic hormones produced and secreted by human cardiomyocyte, form a family of bioactive peptides.
Different types of natriuretic peptides have been identified, the most important being atrial natriuretic peptide (ANP) and brain natriuretic peptide the
(BNP). These are derived from the N-terminal portion of proANP (NT-proANP) and proBNP (NT-proBNP) chains. The study of natriuretic peptide, and
other neurohormonal regulators of the cardiovascular system marked the emergence of a new field of integrated basic and clinical research - cardiovascular
endocrinology. The most commonly used in clinical practice are the natriuretic peptide BNP and NT-proBNP. Although the precursor is synthesized
and released in both the atria and the ventricles, the main source of release is the left ventricle. BNP/NT-proBNP is secreted in response to the increased
tension on the heart wall, as occurs in the case of volume overload of any etiology, and secretion is directly proportional to the degree of wall stress. As
a result, scholars have suggested that determination of the cardiac peptides may be clinically relevant for making an early and rapid diagnosis of heart
failure, evaluating the severity of cardiac insufficiency and wall stress, as well as for monitoring the efficacy of therapeutic measures
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Cuvinte-cheie heart failure, pregnancy complications, natriuretic peptide |
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