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Ultima descărcare din IBN: 2024-04-21 22:18 |
SM ISO690:2012 MOŞIN, Veaceslav, HOTINEANU, Alina, CREŢU, Adrian, SCURTU, Vitalie, HOLBAN, Iuliana. Trombofilia ereditară şi patologia reproductive. In: Buletin de Perinatologie, 2014, nr. 1(61), pp. 35-39. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 1(61) / 2014 / ISSN 1810-5289 | ||||||
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Pag. 35-39 | ||||||
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Rezumat | ||||||
Inherited thrombophilia is a genetic disorder of haemostasis that appears to predispose to blood clotting. Thrombosis have a negative impact (directly or indirectly) to any person’s life. Genetic mutations in genes such as factor V, factor II and PAI-1 can shift haemostatic balance between pro- and anticoagulant forces in favor of coagulation. There is an evidence that inherited thrombophilia may increase the risk of fetal loss, vascular complications of pregnancy (like intrauterine growth restriction or preeclampsia) and consequently it can be a cause of female infertility. Women affected by infertility or pregnancy loss are advised to undergo genetic testing for mutations involved in thrombophilia in order to estimate the risk of thrombosis and decide whether patients need treatment and intervention on risk factors. |
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Cuvinte-cheie thrombophilia, infertility, factor V (Leiden mutation), prothrombin (factor II) G20210A, Plasminogen activator inhibitor 1 (PAI-1) 4G/5G |
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