Subdural Hematoma with Rebleeding under the Anticoagulant Therapy Subdural hematoma is the most common and lethal injury associated with cranial trauma. Unlike epidural hematoma, the subdural hematoma is not always associated with skull fracture, without a direct connection between these two, as the subdural hematoma can appear in the absence of cerebral contusion or any other visible brain injury. The subdural hematoma can be acute, sub-acute or chronic and is the consequence of stretching and tearing of the bridging veins that drain the surface of the cerebral hemispheres into the dural venous sinuses. The etiology of the chronic subdural hematoma is considered to be rebleeding from thin-walled sinusoidal blood vessels from the neo-membrane form around the acute subdural hematoma during its resorbtion. The subdural hematoma are important hemorrhagic complications of anticoagulant therapy and represent 10% of all massive bleedings and 1/3 of all intracranial bleedings associated with oral anticoagulant therapy applied to elderly patients with atrial fibrillation. We render the case of a 78 year old woman, who died being diagnosed with Chronic subdural hematoma on the right hemisphere with rebleeding, Coma, Atrial flutter, Oral chronic anticoagulant therapy. The patients history does not reveal any trauma; the patients had a history of atrial flutter, under treatment with chronic oral anticoagulant and she was committed to a hospital with the diagnosis right hemispheric subdural hematoma.