The values of primary stability and the time dependence of the secondary stability of dental implant can be used to study the formation of bone-implant interface during healing. In present study these parameter were evaluated in vivo. Two implant surface types were used in implantation: machined titanium surface – typically representing a bioinert surface and a chemically treated surface of STI-Bio implants as a representative of the new generation of bioactive dental implants. Physical and chemical characteristics of these surfaces were compared to other commercially available implant surfaces. The results showed that implants with machined surface exhibited a signifi cant stability decrease after implantation. This decrease was leveled off after as long as 11 weeks of healing. The bioactive implants did not show any signifi cant stability change and maintained their stability during the monitored period. The STI-Bio surface also exhibited more favorable values of wetability, surface area and hydration compared to machined surface and other selected commercially available surfaces.