<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'>
<creators>
<creator>
<creatorName>Malic, A.M.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Ustian, A.I.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Lesnic, E.V.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Niguleanu, A.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>The predictive factors for positive molecular-genetic assay in patients with pulmonary tuberculosis from Chisinau city</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2016</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1875-0666</relatedIdentifier>
<subjects>
<subject>tuberculosis</subject>
<subject>Xpert MBT/RIF Assay</subject>
<subject>risk factors</subject>
<subject schemeURI='http://udcdata.info/' subjectScheme='UDC'>616.24-002.5-036.22-07-085(478-21)</subject>
</subjects>
<dates>
<date dateType='Issued'>2016-04-28</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'>Background: One of the most important tuberculosis control action is the early detection, especially of multidrug-resistant tuberculosis. Cultural methods remain the golden standard for pulmonary tuberculosis diagnosis. The microscopic identification of acid-fast-bacilli in sputum is still a worldwide used method for TB detection. The low sensibility of conventional microscopic methods endangers the actual epidemiological situation. Starting with 2012, the genetic-molecular technology – Xpert MTB/RIF Assay - was implemented in the Republic of Moldova. The assessment of initial experience of Xpert MTB_RIF Assay is compulsory for improving the early case detection. The aim of the study is the assessment of extrinsic factors predictable in positive Xpert MTB_RIF patients. Material and methods: A retrospective, selective, descriptive and case-control study was performed. There were enrolled 361 new pulmonary tuberculosis patients, diagnosed and hospitalized in the Muncipal Clinical Hospital of Phthysiopneumology of Chisinau in the period of 01.01.2014 - 01.01.2015. The patients were disributed into 2 groups: I - 174 patients with positive Xpert MTB/RIF Assay result; II - 187 patients with negative Xpert MTB_RIF Assay result. Investigations were performed according to the National Clinical Protocol – 123 Tuberculosis in adults. results: The male gender was predominating above the female gender in both groups: 67,8% vs 32,2% in the 1st group and 55,6% vs 44,4% in the 2nd group. According to the economical status, disadvantaged patients were predominating in the 1st group (71,3%), as compared with the 2nd group (50.8%), with the degree of concludence, p<0,001. The hystory of household TB contact was predominating in the 1st group – 17,2% vs 9,1% in the 2nd group, (p<0.05). conclusions: The implementation of Xpert MTB_RIF Assay improves the early TB detection and the prompt initiation of an adequate treatment regimen, according to the susceptibility testing results. </description>
</descriptions>
<formats>
<format>application/pdf</format>
</formats>
</resource>