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SM ISO690:2012 MAKSYMYUK, V., POLIANSKIY, Igor, HRINCIUC, Fedir, TARABANCHUK, V.. Polymorphism N34S of the spink1 gene in ukrainian patients with different forms of acute pancreatitis. In: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale, 2013, nr. 3(39), pp. 96-100. ISSN 1857-0011. |
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Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale | ||||||
Numărul 3(39) / 2013 / ISSN 1857-0011 | ||||||
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Pag. 96-100 | ||||||
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Background and Aims: We have studied polymorphism N34S of the SPINK1 gene in patients with different forms of acute pancreatitis, living in the Chernivtsi region of Ukraine.
Materials and Methods: The material of the research consisted of 37 persons with different forms of acute pancreatitis.
The patients were subdivided into 2 groups. The first group consisted of 17 patients with acute edematous pancreatitis. The
second group included 20 patients with pancreatonecrosis. All the patients underwent a complex laboratory - instrumental
examination in accordance with the protocol of providing medical care to patients with acute pancreatitis. In addition, a genetic analysis was performed in all the persons for the purpose of studying polymorphism N34S of SPINK1 gene.
Results: In has been established that among patients with different forms of acute pancreatitis the carriage of the
favorable N-allele is more common (45.9% and 51.4%), with a lower number of abnormal SS-homozygotes (2.7%). The incidence of the onset of the biliary form of acute pancreatitis is not associated with a certain genotype of the N34S polymorphism of the SPINK1 gene. The nonbiliary form of acute pancreatitis is insignificantly more common in carriers of the mutant S-allele: 29.7% (11) versus 18.9% (7) persons. Conclusion: The carriage of the unfavorable SS-genotype is a probable predisposing factor of a disease initiation and a potentiation of its further progression. |
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Cuvinte-cheie acute pancreatitis, genotype, polymorphism, SPINK1 gene, mutation N34S |
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