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1276 14 |
Ultima descărcare din IBN: 2022-04-29 21:58 |
SM ISO690:2012 AMBROS, Ala, LÎSÎI, Leonid, CEBOTARI, Inga, RUSU (TEODORU), Daniela, LUŢCAN, Cristina. Monoxidul de carbon – messager gazos în circulaţia cerebrovasculară
. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2010, nr. 1(11), pp. 240-248. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(11) / 2010 / ISSN 1857-1719 | ||||||
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Pag. 240-248 | ||||||
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Carbon monoxide as a gaseous messenger in the cerebrovacular circulation
The primary objectives of this article are to review the potential role of carbon monoxide
(CO) as an endogenous mediator in cerebrovascular circulation. It is produced from heme by a constitutively expressed enzyme (heme oxygenase (HO)-2) expressed highly in the brain and by an inducible enzyme (HO-1). CO production is regulated by controlling substrate availability, HO-2 catalytic activity, and HO-1 expression. CO dilates arterioles by binding to heme that is linked to large conductance Ca2 activated K channels (BKCa channels), which elevates channel Ca2 sensitivity, increases coupling of Ca2 sparks to BKCa channel openings and, thereby, hyperpolarizes the vascular smooth muscle. In addition to dilating blood vessels, CO can either inhibit or accentuate vascular cell proliferation and apoptosis, depending on conditions. |
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