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![]() AMBROS, Ala, LÎSÎI, Leonid, BOBCOVA, Svetlana, PROTOPOP, Svetlana, MATEICIUC, Alexandr. Coagulabilitatea sîngelui în diabet zaharat Tip 2. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2010, nr. 1(11), pp. 233-240. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(11) / 2010 / ISSN 1857-1719 | ||||||
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Pag. 233-240 | ||||||
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Blood coagulation in type II of diabetes mellitus
Diabetes mellitus is associated with diverse derangements in platelet function, the coagulation and the fibrinolitic system. The function of endothelial cells are alliterated, production of prostacyclin by them is reduced, wich partially explain the hyperactivity of the platelets in this disease. The diabetic patient exhibits a pathological coagulation state, with an increased synthesis of coagulation factors and plasminogen activator inhibitor 1 (PAI-1). The insulin exerts a protrombotic role increasing the vascular production of PAI -1, but C-peptide prompts a decrease in vascular PAI-1 expression. Morewer the clots of fibrin in diabetes have thin fibbers and small pores and are more resistant to fibriniolysis. |
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