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SM ISO690:2012 DOBROVOLSKAIA-CATRINICI, Aliona, GUDUMAK, V., MOSHIN, Veaceslav, TODIRAŞ, Mihail. Predictive role of cytokines level in the amniotic fluid and maternal blood
in the possible development of gestational hypertension. In: Curierul Medical, 2013, nr. 4(56), pp. 3-7. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 4(56) / 2013 / ISSN 1875-0666 | ||||||
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Pregnancy induced hypertension, which includes both gestational hypertension (GH) and preeclampsia, is the most common medical disorder and remains one of the major causes of maternal and fetal death. The pathogenesis of GH is still unknown, yet immunologic and inflammatory causes may play an important role in the pathophysiology of this disease. The purpose of this study is to investigate the midtrimester IL-6, IL-8, IL-10, IL-12, TNF-α, SDF-1a and VEGF in the amniotic fluid (AF) and maternal blood regarding the above as being predictive for the gestational hypertension outcome. In the group of 128 pregnant women over 35 years old the six ones have developed GH. Our study results demonstrate that GH is associated with a strong increase of IL-6, IL-12 in maternal blood and a significant decrease of serum IL-10. Although AF level of both IL-6 and IL-10 has been significantly lower in GH subjects. In conclusion this study shows the relationship between the midtrimester IL-6, IL-12 and IL-10 concentrations in AF and maternal
serum and GH outcome. |
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Cuvinte-cheie gestational hypertension, pregnancy after 35 years old, amniotic fluid, maternal serum, cytokines |
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