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SM ISO690:2012 COTELEA, Tamara, CIORICI, Mihai, SLONOVSCHI, Grigore, LÎSÎI, Leonid. Studiul intoxicaţiilor cu clozapină. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2009, nr. 1(10), pp. 344-348. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(10) / 2009 / ISSN 1857-1719 | ||||||
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Pag. 344-348 | ||||||
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The study of intoxication with clozapine
Clozapine is a neuroleptic- antipsyhotic atipical derivative of dibenzodiazepine which
offered the patiens with schizophrenia the chance to a better life resistent to classic neuroleptics but its treatment made also victims from the momentof its introduction in the treatment due both to its side effets and interactions with other medicines. Clozapine has a strong neuroleptic action with a sedation effect which occurs immediately after its administration which determined an abuse of its taking as a drug to induce a narcotic intoxication state. Due to the close therapeutical
concentration (0,2-0,8 μg/ml) and of the toxic one (0,8-1,3 μg/ml) in blood plasma, numerous cases of intoxication were described with this drug. |
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