The article is focused on determining the economic efficiency and arguing the economic calculations connected with the economic efficiency of the melliferous bees breeding within the agricultural farms of the Republic of Moldova. In order to make an analysis, the author proposed the idea of creating a model apiary breeding 10 and 50 families of bees, the one that can be implemented and managed within a family farm. The economic calculations connected with melliferous bees breeding have been done taking into consideration the following aspects: assessment of the necessary investments, planning the annual revenues from sales, calculation of the annual consumptions and calculation of the final economic results. As a result of practicing the entrepreneurship activity within this apiary designed for melliferous bees breeding, we determined that it is possible to obtain a sufficient annual profit for further development of the mentioned business.