Introduction. Patients with localized prostate cancer are candidates for surgery, radiation therapy, or active surveillance. Open retropubic prostatectomy (ORP) is the most common surgical treatment in the Republic of Moldova. Aim of study. Were to evaluate the effectiveness of ORP and to study early and long-term postoperative outcomes in patients with localized prostate cancer. Methods. In the period from June 2021 to February 2023, ORP was performed in 20 patients with localized prostate cancer at the Urology Department of the IMSP SCR «Timofei Mosneaga». The mean age of the patients was 67.3 years. The mean preoperative PSA was 12 ng/ml. In 8 patients (40%) was determined a low risk of biochemical recurrence, in 8 patients (40%) was established intermediate risk and in 4 patients (20%) high risk of biochemical recurrence. According to the TNM classification for prostate cancer (2017), the distribution was as follows: T1a – 2 patients (10%), T1c – 14 patients (70%), T2a-T2c – 4 patients (20%). Extended pelvic lymphadenectomy preceded prostatectomy in 9 patients (45%). Results. Among the intraoperative complications, there was bleeding from the veins of the Santorini plexus in 3 cases. In the postoperative period, one patient had prolonged lymphorrhea. The median number of days a patient spent in hospital after surgery was 8 days (3-25). Removal of the urethral catheter was performed on the 3-4th week. Urinary continence was restored in patients within six months after surgery. Conclusion. ORP is an effective surgical method for treatment of clinically localized prostate cancer with low level of postoperative complications.