Introduction. The data from the several studies have observed and was demonstrated tissue damages after ESWL in treated kidneys, such as pathologic changes - interstitial hemorrhage and parenchymal edema, damage of renal tubular cells and vascular spasms. Material and methods. Trying to confirm and further to investigate this clinical pathogenetic possibility, we aplly the Doppler ultrasound evaluation to demonstarte thye changes of renal blood flow velocity in 45 patients with renal stones who underwent ESWL treatment for kidney stones. The studies were conducted before, immediately after and 2 weeks after an ESWL treatment. Results. Were evaluated and was demosntrated the kidney blood flow velocity decreased significantly in the area were was applyed shock wave lithotripsy after the treatment and returned to the initial stage levels after 2 weeks. The changes were not detecting significant in the non-exposed area. Concomitent were abserved significantly decrease of kidney blood flow velocity, significant increases of vascular resistive index, pulsatility vascular index and significant decreases of vascular ratio were observed. These parameters were evaluated by measuring of kidney blood flow velocity and its direct correlate with parenchymal vascular resistance. Its a hight probability that the changes in kidney parenchymal blood flow velocity are triggered by the tissue damages exposure shock wave litotripsy treatment. The recovery of kidney blood flow velocity can be in significant correlation to the recovery of the tissue exposure damages. Conclusions. The possibilities to use the ultrasound color Doppler method in clinical practice can be a novelty tehnology to evaluate the state of vascularization in kidney parenchima after ESWL, and can be an important clinical factor to determine when to repeat and to minimalize the developent of major complications.