Introduction. Approximately until 90% of renoureteral stones have for treatment indication Extra Corporeal Shock Wave Lithotripsy (ESWL). We like to report our 12 years of experience with over 7250 patients with reno-ureteral stones treated with ESWL. The success rate of treatment is very high, and depending on the stone composition, stone density in Hounsfield units, size and location of stones. Material and methods. The study included 7250 patients (4567 males, 2683 females, aged 18– 85 years old) treated with ESWL between 2011 and February 2023. The stone diameter was in medium 14 mm. Like a therapeutic procedure, ESWL may be accompanied by complications. Most of these complications are minor complications, but in a lower percentage, major complications can be developed. We statistical analyzed stone free rate, procedure time and complications. Results. After first episode of treatment the total stone-free rate was 67 %. From total number of 7250 patients, 9340 of ESWL procedures were made. After the second procedure, the stone free rate 83 % for ESWL. The mean operating time was 37(±5) min for ESWL. From the minor complications was: lumbar pain, hematuria and transitional fever. Major complications – acute obstructive pyelonephritis in 1,1 % of patients, renal subcapsular hematoma 0,57 % and „steinstrasse” in 5,8 % of patients. The unsuccessful rate after ESWL was 17 %. Conclusions. ESWL is a safe method to treat stone disease with high rate of “stonefree” when proper indications are followed. In majority of cases after procedure the complications are minor but can appear and the major complications.