This research paper reports on a theoretical and practical research into the process of assessing human potential in higher education institutions. The paper aims to assess the potential of higher education institutions in the Republic of Moldova, i.e.“Alecu Russo” State University of Bălți(USARB), the Academy of Economic Studies of Moldova (ASEM), the State University of Moldova(USM), the Technical University of Moldova (UTM) and also “Alexandru Ioan Cuza” University, Romania (UAIC). In order to develop this research, we employed the following methods: induction, deduction, abduction, analysis, synthesis, quantitative research, scientific abstraction. Within this context, a quantitative research was performed using investigation, the research tool being the survey. In conclusion we can say that one of the important factors that contribute to the emergence of sustainable innovation-driven university development is the innovation culture and the establishment of innovative cultural values within universities.