World wide experience during COVID-19 pandemic disclosed that the endodontic pathology prevailed among all dental emergencies. The endodontist have to handle a large category of patients: COVID-19 positive, either symptomatic or asymptomatic, and unsuspected/nonactive. To minimize the cross-infection risk a rapid and accurate triage is highly asked since the suspected and active patients should be referred to the dedicated dental settings. In stabilized COVID-19 patients it is pivotal to carry out the treatment of endodontic emergencies as much as possible in a definitive and not palliative manner due to the risk of unpredictable worsening of clinical evolution.