This research aims to propose a comprehensive theoretical model that corroborates the findings regarding the application of the requirements of the UN Agenda and the Learning Compass 2030, regarding universities as agents of change for sustainable development. We believe that this model is welcome among universities considering the difficult period of adaptation that higher education underwent due to the COVID-19 pandemic. To achieve the proposed aims, the present research is based on a holistic interdisciplinary approach that allows us to present the importance and role of higher education in sustainable development. In a first step, the present research was based on the analysis of the literature to identify the research gap to contextualize the influence of higher education on its probable position on sustainable development. The result of the review of the literature and the documents issued by UN and OECD is materialized in the proposal of the comprehensive model as a transformation mediator for sustainable universities. Our research responds to an essential need in today's society and supports universities to systematize the vital role they play as key actors in the sustainable progress of culture and the economy.