The system of the world economy presents a complex set of interdependencies between its subjects, the continuous adjustment of which is an imperative of the contemporary stage. There are a lot of factors that contribute, others prevent the maintenance of the concordance of international economic relations at the level of the development of the factors of production. Hyperglobalization is among the positive factors, which ensured an unprecedented increase in prosperity in the period 1990-2008. The global crises are at another pole, a negative one, which practically caused the economic recession we are witnessing, and which stopped the expansion of interdependencies between the subjects of the world economy in the last period. The pandemic crisis and Russia's invasion of Ukraine, which threatens to throw the economic development process around the world back several decades, have become insurmountable obstacles in the economic development process. In that article, an attempt is made to identify certain ways, which could elucidate the problem of adjusting the interdependencies between the subjects of the world economy system at the level of the development of the economic potential of the countries of the world by limiting the areas of action of the economic interdependencies at the regional level. Such an approach would not mean the refusal of the global dimension. Inverse. This would involve ensuring a more orderly concordance of interdependencies and production forces at the regional level by promoting global values, through integration and peaceful adaptation to change, simultaneously with the development of viable global systems, institutions and norms. It would be a new regional dimension of economic development strategies around the globe. In this sense, the article analyzes to what extent the transition from global to regional, as the main trend of this dimension in the world economy, contributes to the adjustment of the set of interdependencies at the level of development of production forces. Could the expansion of BRICS with six new members be an example of this adjustment, or will it lead to even greater global instability by intensifying confrontations between the OECD and the BRICS, between the G7 and the E7?