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616.853-053.2-07 (6) |
Neurologie. Neuropatologie. Sistem nervos (971) |
SM ISO690:2012 ISTRATIUC, Irina, CALCII, Cornelia, , , ANTOHII, Ana, CAPESTRU, Elena, CALISTRU, Iulia, CONSTANTIN, Olesea, FEGHIU, Ludmila, HADJIU, Svetlana. West syndrome: clinical and paraclinical features. In: Registrul maladiilor reumatice la copii: experiența Republicii Moldova, 31 martie 2023, Chişinău. Chişinău: Taicom (Ridgeone Group), 2023, p. 83. |
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Registrul maladiilor reumatice la copii: experiența Republicii Moldova 2023 | ||||||
Simpozionul "Registrul maladiilor reumatice la copii: experiența Republicii Moldova" Chişinău, Moldova, 31 martie 2023 | ||||||
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CZU: 616.853-053.2-07 | ||||||
Pag. 83-83 | ||||||
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Introduction. West Syndrome (WS) is one of the most common causes of epilepsy in infants and young children. WS is composed of the triad of infantile spasms, an interictal electroencephalogram (EEG) pattern termed hypsarrhythmia, and mental retardation. WS is a devastating brain disorder and prognosis is one of the worst among childhood epilepsies. The purpose of the study was to elucidate the clinical and paraclinical features of WS, and to show pathognomonic characteristics for early approach to diagnosis. Material and methods. Was examined 430 patients up to the age of 2 years, who was admitted to IMPH MCI, who presented in complains the convulsive attacks. The 16 (13,4% of them presented epileptic spasms). The patients were examined by the neurological, encephalographic, qualitative immunology and neuroimaging methods. The statistical evaluation was performed by the ratio method. Results. From 430 patients – 16 (3,7%, ES 0,91) of them had the complains: sudden movements in upper and lower limbs, which occurred serially on awakening, 14 (3,2%, ES 0,85) of them presented retardation in neuropsychic development, in 11 (1,5%, ES 0,75) patients the electroencephalographic diagnosis of SW was confirmed. Electroencephalographic results in WS showed changes: 9 (81,8%; ES 11,63) patients – typical hypsarrhythmia and 2 (18,2%, ES 11,63) patients – modified hypsarrhythmia. The result of qualitative immunological examination for CMV and HSV shows the results: patients which was diagnosis with WS presented; CMV IgM – 1 (9,09%, ES 8,67), CMV IgG positive – 8 (72,72%; ES 13,43); HSV IgM – patients were negative, and HSV IgG positive – 10 (90,90%; ES 8,67). MRI imaging confirmed the diagnosis of tuberous sclerosis in 1 (9,09%, ES 8,67) patients. Molecular-genetic exams was recommended for patients whose cause was not found. Conclusions. The results of the study shows that the SW remains one of the most common forms of epilepsy in children, which is characterized by specific clinical features and characteristic electroencephalographic tracks, the causes of disease are polymorphic with involvement brain structure. |
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Cuvinte-cheie epilepsy, infantile spasms, infantile spasms, hypsarrhythmia, West syndrome |
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