Introduction: Depression affects approximately 3.4% and sleep disorders approximately 10% of the global population, having a significant impact on socio-economic aspects, quality of life and individual functioning. The comorbidity of these conditions, requires further investigation to reveal the underlying mechanisms, risk factors and their impact on mental health. Methods: We conducted a study of 23 patients, diagnosed with depression. We used the following instruments and methods for data collection: the Structured Interview for the Assessment of Depression (SCID), the Pittsburgh Sleep-Quality Index (PSQI), the Depression Severity Scale (HAM-D) and the Quality of Life Scale (QoL). Results and discussions: We identified the following sleep disorders among patients with depression: insomnia 58%, hypersomnia 16%, circadian rhythm disorders 14%, sleep breathing disorders 12%. The identified risk factors: chronic stress 64%, family history of depression 42%, excessive caffeine consumption 36% of patients. Analysis of depression severity showed that patients with depression and sleep disturbances had higher mean scores on the HAM-D. The score was 21 in this group, compared with a mean of 18 for depressed patients without significant sleep disturbances. Patients with depression and associated sleep disturbances scored lower on the QoL scale compared to those without sleep disturbances. The mean QoL score was 48 for the group with comorbidity, and 56 for those without