Introduction. Preeclampsia remains a challenge in obstetrics, various biomarkers have been studied that could predict early preeclampsia and reduce its complications. Recently, the marker hypoxiainducible factor 1α (HIF-1a), which is a mediator of the hypoxic stress signal, has been studied, and the HIF-1α protein level may be increased in preeclampsia. Material and methods. The concept of the study consists in the development of the prognostic model that is able to predict the probability of occurrence of preeclampsia using HIF-1α as a covariate. A prospective cohort study was carried out, in which 96 pregnant women in the third trimester of pregnancy were included, which was divided into two groups: the study group - 48 pregnant women with preeclampsia, the control group - 48 pregnant women without preeclampsia. Results. According to the coefficients obtained through the regression and resampling analysis, the proposed equation is recommended for use in practice, including the risk estimation for each pregnant woman. Has been established: Nagelkerke R Square = 0.734 (73.4%), calibration (χ2 = 13.498, df = 8, p = 0.096) and discrimination (Sensibility 93.8%, Specificity 90.2%), HIF-1α (B = 0.013, 95% CI 0.008, 0.018), OR = 1.013 (95% CI 1.008, 1.018). Conclusions. Taking into account the characteristics of the model, it can be considered relevant, and HIF-1α, in turn, can be considered a new biomarker for predicting the risk of preeclampsia.