Introduction. Parvovirus B19 (B19V) is a singlestranded DNA virus from the family Parvoviridae, the genus Erythrovirus. The 5 syndromes associated with PV-B19 are: erythema infectiosum (5th disease), athropathy, transient aplastic crisis, fetal infection leading to fetal hydrops, red blood cells aplasia. It occurs in outbreaks among school-aged children, although it can also occur in adults. Clinical case. We report the clinical case of a 16-year-old child, previously healthy, who came to the Emergency Department of the Municipal Clinical Hospital of Contagious Diseases for Children, with low fever 37.5 ˚C, rash, odynophagia, repeated vomiting, headache , general weakness, with an onset 4 days earlier. In outpatient department was administered antipyretics and desensitizers, without improvement. The physical examination revealed an erythematous rash, "slapped" appearance on the face, with circumoral pallor. Subsequently, pruriginous, reticular eruptions with lacy edges appeared on the trunk and extremities. At the periarticular level of the hands and feet, the eruption gets a papulo-purpuric appearance, "gloves and stockings". The clinical examination revealed follicular purulent deposits on both tonsils and enlarged, mobile laterocervical lymph nodes.As a result of clinical and laboratory investigations (excluding Yersiniosis, infection with EBV, CMV, HSV, rheumatoid arthritis, allergic dermatitis) the diagnosis of Parvovirus-B-19 infection was established.Erythema Infectiosum (B19V DNA positive by PCR).The treatment included hypoallergenic diet, desensitizers, antibiotic therapy, antipyretics. The eruptions subsided 2 weeks after the onset of the disease. Conclusion. Parvovirus B19 infection manifets most often in school-aged children, as a mild, selflimited prodromal illness with an erythematous rash on the face. In adolescents and young adults, it develops with the papulo-purpuric ,,gloves and stockings” syndrome, located periarticularly with distinct edges on hand and ankle joints, sometimes associated with transient arthropathy.