Introduction. Acute diarrheal diseases are a major problem among preschool children. It is estimated that in recent years, diarrhea accounted for 9.9% of the 6.9 million deaths among children under 5. Material and methods. Is presented the clinical case of a child with salmonellosis hospitalized in the Municipal Clinical Hospital for Contagious Diseases Children. Results. A 3-year-old girl presented on the 2nd day of illness with complaints of fever up to 39°C, 8 stools/24 hours (Bristol -7), abdominal pain, pronounced weakness, hyporexia, thirst, headache, and vertigo. Antimicrobial therapy with Nifuroxazide and symptomatic therapy was initiated. On the treatment background, the condition was improved, with the reduction of the number of stools up to 1-2/24h, the fever decreased. On the 7th day, the condition worsened, the fever reappeared up to 38.8°C, 5 liquid stools/24h and vomiting (7 times/24h). The bacteriological examination revealed Salmonella Enteritidis sensitive to imipinem, cefepime, cefotaxime, ceftazidime, ceftriaxone, chloramphenicol, ciprofloxacin, ertapenem, levofloxacin, meropenem, moxifloxacin, ofloxacin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole. In the initial treatment, the antimicrobial therapy was changed to Cefatoxime, and symptomatic therapy continued. On the treatment background, liver and inflammatory markers in regression. The child was discharged on the 14th day, with the clinical diagnosis: Salmonellosis caused by Salmonella Enteritidis, gastroenterocolitic form, severe evolution. Reactive pancreatitis. Toxic hepatitis. Nutritional anemia 1st degree. Conclusions. Diarrheal diseases have a negative impact on health. In order to avoid the occurrence of longterm disabilities, it is necessary to identify the causative agent and the multidisciplinary approach.