Introduction. Studies have shown that benign distal biliary strictures (BDBS) may be associated with scarring due to an episode of gallstone passage. Commonly, patients with BDBS present with recurrent cholangitis and mild jaundice. This study aims to assess the efficacy of endoscopic sphincterotomy (EST) guided by endoscopic retrograde cholangiopancreatography (ERCP) for the definitive treatment of BDBS. Material and methods. The paper included 79 patients with BDBS diagnosed by specific clinical symptoms, laboratory tests, and imaging studies. Of these patients, 67 were women (84.8%) and 12 – men (15.2%), with the mean age 63.2±7.8 years (range 34-78 years). The history of cholecystectomy had 57 (72.2%) patients, including 9 (11.4%) with additional common bile duct stones clearance. Of the 22 non-operated patients, gallbladder stones were diagnosed in 17 (77.3%). Results. All patients underwent endoscopic therapy, including duodenoscopy, cannulation of the major duodenal papilla (MDP), ERCP and EST. The use of a certain sphincterotome (“pull-type”, “push-type”, “needle-type”) depended on the location and anatomical shape of MDP, as well as the length and degree of stricture. In all cases, BDBS was eliminated and normal bile flow was restored. Complications, mainly pancreatitis, were noted in 8 (10.1%) cases. Conclusions. ERCP-guided endoscopic sphincterotomy is an effective and relatively safe method for treatment BDBS with recurrent cholangitis and, in selective cases, may serve as an alternative to open surgery.