Introduction. Transforaminal percutaneous endoscopic discectomy (DEPT) is an innovative technique with local anesthesia and minimally invasive incision from lateral approach, allows safe removal of lumbar disc herniations under endoscopic visualization with early rehabilitation. Objective. To analyse the efficiency of surgical treatment in patients with lumbar disc herniation using the transforaminal percutaneous endoscopic method. Material and methods. This is a prospective study of 55 patients (39 males, 16 females) with different localizations of lumbar disc herniation: level L5 - 25 subjects, level L4 in 28 subjects, level L3 - 2 patients; central, paracentral, intraforaminal extraforaminal herniations were found in nine (16.36%), 18 (32.72%), 26 (47.27%) and two (3.63%) cases, using exclusion criteria. Patients’ age range 20–62 years, mean ±38 years. Follow-up at 1, 3, 6, 12 months after DEPT was done using VAS and MacNab scales. Results. The findings of our study showed that MacNab score was excellent 47 (85.45%) cases, good seven (12.72%) cases, and satisfactory one (1.81%) case. The preoperative mean was VAS 6.71±1.52, postoperative mean VAS 3.1±1.3 and rebound 2.2±1.3 (P < 0.0001). Regarding complications, recurrence occurred in two (3.63%) patients, but there were no cases of conversion to open surgery, infection or discitis. The operating time 58±4.6 min and intraoperative hemorrhage 9±1.2 ml. Average verticalization in 2.2 ± 0.5 hours. Sameday or next-day discharged with normal activity in 7-10 days postoperatively. Conclusion. DEPT is safe and complete removal of lumbar disc. Superiority in outcomes, gives the potential as a golden standard for lumbar disc disease.