Introduction. Diabetes mellitus (DM) is a chronic hyperglycemic condition, exposure to high glucose levels leading to a series of biochemical, structural and functional changes of the mature vascular endothelial cell and vascular smooth muscle cell. Due to compromised immune and vascular systems, patients with DM become susceptible to fungal infections. Material and methods. We present an analytical, clinically controlled study realized on a group of 46 patients with DM type 2, who presented microvascular changes in the lower limbs associated with tinea pedis. The diagnosis of tinea pedis was confirmed by microscopic and culture examination while the microvascular changes - by periungual digital capillaroscopy. The patients were divided into 2 equal groups: group 1-followed standard antifungal treatment and group 2-standard antifungal treatment in association with Sulodexide. The evaluation of the effectiveness of the treatment was realized on the 45th and 90th day of treatment. Results. The fungal culture test revealed Tr.rubrum in 35 patients 76.1%, Tr.mentagrophytes in 11 patients – 21.7% and Epidermaphyton floccosum in 1 patient – 2.2%. On capillaroscopic examination, patients presented giant capillaries, architectural disorganization, multiple branched capillaries, crossed capillaries, loss of capillaries or even extensive avascular areas. At the microscopic and culture examination on 45th and 90th day of treatment, only 25 patients (54.3%) presented a negative culture result in first group comparative to 33 patients (71.7%) in the second one. Conclusions. It is recommended to remedy the microvascular abnormalities in the diabetic foot complicated with tinea pedis in order to obtain better therapeutic results.