Introduction. Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis, characterized by painful and ulcerating lesions on the skin, with a spectrum of clinical presentations and variable clinical course. It can be a rare complication of Herpes Zoster. Material and methods. A series of 2 patients with a final diagnosis of Pyoderma Gangrenosum is presented. First case of 61-years-old immunocompetent woman presented with a history of multiple intensely pruritic vesicular eruption, pronounced right axillary fossa pain syndrome and subsequent crusting. After the detachment of the crust, an ulceration of 5-6 cm in diameter appeared with an intensely erythematous base where the underlying muscle and fascia can be seen. The second case shows a 64-years-old immunocompetent woman with a three-week history of herpetic eruption involving the submammary folds. Persistent painful ulcers with undermined bluish borders with surrounding erythema developed after 2 weeks. Results. Both patients were diagnosed with pyoderma gangrenosum as a complication after Herpes Zoster based on history and evolution, clinical symptoms and morphology of the lesions. Conclusions. Pyoderma gangrenosum is an idiopathic, inflammatory, ulcerative disease with a chronic, relapsing course of undetermined cause that can progress quickly. In larger series, about 50% of patients show an underlying disorder. The diagnosis is based on clinical and pathologic features and is one of exclusion of conditions that produce ulcerations. Biopsy will not make the diagnosis but can be used to rule out other causes. Hospitalization is helpful for cases with significant wounds. Early treatment can help reduce the risk of scarring.