Introduction. Herpes zoster occurs due to the reactivation of the latent varicella-zoster virus. The disease presents as an erythematous-vesicular eruption with a dermatomal distribution. Herpes zoster ophtalmicus results from the involvement of the ophthalmic branch of the trigeminal nerve, being considered an ophthalmological emergency. Material and methods. We present a prospective case series involving a 5-month-old patient and an 86-years-old patient, treated at the Hospital of Dermatology and Communicable Diseases with the diagnosis of Herpes zoster ophtalmicus. Case 1. A 6-day history of illness in a 5-monthold child, hospitalized with eruptions on the left cephalic region. The physical exam presented an erythematous vesicular rash on the edematous base. Cervical lymph nodes were increased up to 0.5-0.6 cm. Changes in the general status of the child were not observed: the consultation of the neurologist and the pediatrician did not find any somatic changes. Case 2: A 8-day history of disease in an 86-years-old patient with an excruciating burning pain followed by the outbreak of vesicles localized in the left cephalic region. On physical exam we revealed grouped hemorrhagic vesicles and crusts. Conjunctival injection was attested in the left eye. The ophthalmologist established the diagnosis of an acute keratoconjunctivitis. Paraclinical investigations didn’t show significant deviations. Conclusions. Herpes Zoster is a rare disease in infants. Herpes zoster ophtalmicus often occurs in a more severe form and is difficult to treat, both in adults and children, as well as severe vision loss eye complications can develop. Antiviral treatment protocol is crucial in preventing them.