Introduction. Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a type of cutaneous T-cell non-Hodgkin’s lymphoma (NHL), characterized by presence of anaplastic large lymphoid cells CD30-positive. Clinical manifestations are characterized by single or multifocal nodules that ulcerate, are autoregressive and recurrent. The lesions usually occur on the trunk, face, extremities and buttocks, usually being asymptomatic. Material and methods. Prospective clinical study of a patient with primary cutaneous anaplastic large cell lymphoma. Results. A 5 years history of disease in a 45-year-old man with skin lesions on the face, upper and lower limbs, and body. First manifestations were characterized by disseminated skin xerosis and chronic eczemas. From January 20, 2023, nodular formations appeared located on the calves, neck, upper limbs, groin, accompanied by a fever of 39C. Over time the lesions increased in volume. Dermatological status: nodules of different sizes 1-4 cm in diameter are observed on the face, upper and lower limbs and trunk, on the surface of which there are adherent, sero-purulent crusts. In some areas nodules are without ulcerations, of different sizes 0.5-3cm, hard to the touch, painless with unchanged surface. The biopsy was taken, which revealed specific modifications for PC-ALCL. Thoracic and abdominal CT revealed systemic involvement. Conclusions. First appearance of PC-ALCL can be prolonged cutaneous xerosis and recidivate eczemas. The incidence of PCALCL among other types of peripheral T-cell NHL is 1.7%, that is why it can be misdiagnosed. The treatment of choice is brentuximab vedotin. If not treated, can lead to systemic form and death.