The global pandemic event that took place in 2020 had major negative repercussions on the economies of the world. Aiming to stabilize financial markets and cushion the contraction of the real economy, the central banks’ response was swift and unprecedented. They initiated a series of non-conventional monetary measures, aimed at ensuring favorable financing conditions, providing liquidity and new credit facilities to the financial system, ensuring the smooth functioning of the financial market and providing liquidity in foreign exchange. The purpose of the article is to analyse the particularities of the use of unconventional instruments by developed and emerging economies during the pandemic. Also, considering the major role of the ECB for the financial system of the euro area, of the European Union, but also for the world financial system, our article analyses the set of instruments used by the European monetary authority in the context of the pandemic event. This article is based on broader research developed by the author as part of the 2022 Institute for World Economy study - Unconventional Approaches of Central Banks in the Pandemic Crisis. The financial and economic implications in the states of Central and Eastern Europe - Coordinator Dr. Habil. Mihai Nițoi.