Due to the individual implications it has for physical and mental health, as well as for the well-being of family members, the psychosocial issue of chronic diseases among adults attracts the attention of researchers. This study adds to the efforts aimed at identifying the protective and risk factors that professionals in the field of psychosocial assistance services must take into account when assessing the emotional and behavioral problems of the beneficiaries they assist and in establishing a psychoeducational intervention plan. The paper highlights the role of psychosocial education in increasing the quality of life of people with chronic disabilities following a stroke. Through the long-term consequences they have, chronic disabilities are a major risk factor for individual development and for the functioning of a family system. Chronic medical conditions are the main risk factor for mortality all over the world, which is why they attract increasing interest from researchers in various fields. Considering the complexity of the psychosocial universe of chronic diseases, this paper comes with a series of conceptual and applied aspects useful to researchers in the fields of health psychology, clinical psychology, couple and family psychology, health sociology, etc., as well as to practitioners in the fields of psychological counseling, psychotherapy, medical and social assistance. The results highlighted the predictive role of certain individual, familial and extra-familial characteristics in relation to the psychosocial adaptation among caregiver.