In modern conditions, the problem of developing biological protection of fruit and berry crops on the basis of a scientifically based combination of organizational-economic, agrotechnical, mechanical, genetic, biological and other measures aimed not only at limiting the harmfulness of diseases and pests, but also at improving the health of garden agrocenoses, environment safety and cultivation of competitive horticultural products. Strategies of biological control should be based on management of the populations of harmful organisms using their natural antagonists, biologically active and biological agents in order to stabilize the ecological balance in garden. The research was conducted in 2019-2020 in the right-bank part of the western Forest Steppe of Ukraine. The following bioinsecticides were used: Naturgard (extract of Sophora seeds), Scarado M (Bacillus thuringiensis var. thuringiensis, B. thuringiensis var. kurstaki), Sezar (Pseudomonas B-306, Streptomyces avermitilis and chitosan). Experiments were carried out in plum plantations of Institute of Horticulture on cv. ‘Stanley’. The main pests were gray bud weevil (Sciaphobus squalidus Gyllenhal), black plum sawfly (Hoplocampa minuta Christ.), plum seed wasp (Eurytoma schreineri Schreiner), plum fruit moth (Grafolita funebrana Tr.), mealy plum aphid (Hyalopteus pruni Geoffr.). Biological insecticides showed high efficiency against gray bud weevil, black plum sawfly and mealy plum aphid. The most effective against gray bud weevil was Sezar (73-86%). Scarado M and Sezar showed high level of control of black plum sawfly (73-93%). Naturgard and Scarado M were the most efficient against mealy plum aphid 75-80%. Control of other pests was lower (upto 44-62%). So, application of bioinsecticides can provide control of the main pests of plum to a large extent. They have the potential to be used in plant protection systems when growing organic products.