Background: the purpose of our study was to investigate the correlation of the processes of angiogenesis and epithelization defects of the gastric mucosa in experimental models of gastroduodenitis of laboratory animals. Material and methods: In the experiment used 30 purebred female albino rats with average weight of 250 g. The rats of both series received 3% acetic acid solution 2 times a day per os for 7 days. Thus, in animals was induced by experimental gastroduodenitis, accompanied by erosive defects of mucous membranes of esophagus, stomach and duodenal. Then the rats were divided into 2 groups: the control, which consisted of 15 animals watered daily with 1.0 ml of physiological solution; experienced (15 rats) animals, which was orally given solution of 1.0 Vesugene every day. After 5 and 10 days of application of these substances in animals of all series were taken the bioptites of gastric mucosa for histological examination. The material of biopsy specimens of the mucosa was assessed under the light microscope. Results: to optimize the reparation cytogeneVesugene was used. It is a peptide complex containing amino acids such as lysine, glutamic and aspartic acid. Vesugene is able to stimulate the reparation of vascular wall cells to improve the functional condition of blood vessels. On day 5 of the experiment in animals of the control series were more expressed signs of the presence of cellular, vascular and intravascular coagulation-lytic syndrome. The same pattern was observed on the 10th day of the experiment.Comparative analysis of epithelization defects of the mucosa and of microcirculation in the affected area in the compared groups during all time of study have shown a clear dependence of the regeneration of epithelium and angiogenesis in the zone of formation of granular tissue that fills the defect. Conclusions: Animals of the experimental series in dynamics reliably demonstrated the high efficiency of the repair processes, expressed in the acceleration of epithelization and angiogenesis.