The synergistic effect becomes evident as the combined impact of multiple agents is not simply the sum of their individual effects. Instead, it results in the simultaneous impairment of various human organ systems by different types of limiting factors, leading to more severe consequences within the organism. In this paper, the researchers aim to elucidate the common feature shared by all synergistic chemical processes. Frequently, this common element remains concealed, leading to diverse interpretations of the synergism phenomenon. These interpretations vary based on the specific chemical processes under investigation, including their unique characteristics such as the chemical structures of the reagents involved, their mechanisms, kinetics, energy considerations, and more. The study encompasses a comprehensive analysis of various chemical processes employed in different physico-chemical research methods across various fields of application. Our research has been established that the unifying aspect of the synergism phenomenon in all these processes is the formation of a mixed compound/complex. Recognizing this shared characteristic in advance provides an opportunity for a deeper comprehension of this phenomenon and facilitates the targeted exploration or prediction of necessary or pre-planned synergistic effects. Frequently, this common feature remains concealed, remaining “hidden”, and as a result, the phenomenon of synergism finds various explanations. These explanations vary depending on the specific chemical processes under scrutiny and their unique attributes, including the chemical compositions of the reagents in question, their mechanisms, kinetics, energy considerations, and more. Hence, when a synergistic effect arises from a chemical process, it is essential to recognize that it entails the formation of a mixed complex, which can exhibit diverse characteristics. These identified relationships can be leveraged in the exploration and development of novel synergistic processes tailored to specific desired properties. Thanks to these inherent properties, the systems under examination have the potential for extensive applications across various domains of chemical and biochemical research. This versatility extends to fields such as analytical chemistry, pharmacology, pharmaceuticals, the medical industry, and synthetic organic chemistry. Future research on chemical synergism should focus on isolating and characterizing more mixed compounds prior to their use in further reactions, as well as providing more detailed thermodynamic and kinetic knowledge, supported by theoretical calculations, since understanding is currently based mainly on empirical observations