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![]() STRATULAT, Silvia, ȘALARU, Gabriela, ALEXA, Zinaida. Modificările glicemiei și indicilor metabolismului lipidic la pacienţii cu Covid-19. In: Revista Farmaceutică a Moldovei , 2022, nr. 2(50), pp. 20-28. ISSN 1812-5077. |
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Revista Farmaceutică a Moldovei | ||||||
Numărul 2(50) / 2022 / ISSN 1812-5077 | ||||||
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The SARS-CoV-2 virus triggers the COVID-19 infection, which produces changes both local, characterized by pneumonia or acute respiratory distress syndrome (ARDS), and general, due to the cytokine storm, characterized by pronounced toxic-infectious syndrome, specific to severe forms. Researchers are continuously studying the respective pathology, thus, any changes in the laboratory indices are important for the development of early diagnosis strategies, the identification of a specific treatment to eradicate this virus and prevent and/or neutralize the immediate and lasting negative effects. The aim of the study was to evaluate the clinical features and changes in blood glucose, lipid metabolism indices in patients with COVID-19 depending on the association of diabetes and the evolution of the disease in order to optimize the behavior of the patient with COVID-19. A transversal observational research was conducted. The study was conducted on a representative sample of 1000 patients with COVID-19, divided into 2 groups depending on the association of diabetes and the evolution of the disease. The following were analyzed: anthropometric data (weight; waist, BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP), oxygen saturation. The application of biochemical and immunoenzymatic methods allowed the evaluation in serum of: glucose, glycated hemoglobin and indices of lipid lipid metabolism (triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol). In patients with COVID-19 and Diabetes compared to patients with non-diabetic COVID-19, the following is noted: significant increase in BMI; TAS. Regardless of the association of diabetes, there were significant differences in older age and decreased oxygen saturation in patients who died versus survivors. Blood glucose and HbA1C values are significantly increased in patients with COVID 19 and Diabetes compared to non-diabetic patients. They undergo significant fluctuations in dynamics: they decrease in diabetic and non-diabetic patients with COVID-19 who survived and continue to increase reaching maximum figures (on the 10th day of hospitalization) in patients who died in both groups. In patients with COVID-19 and Diabetes compared to non-diabetic COVID-19 patients who survived, the increase in triglyceride levels and the tendency to decrease total cholesterol, LDL-Col and HDL-Col are revealed in deceased COVID-19 patients compared to survivors. In conclusion: the abnormalities of the anthropometric indicators as well as those of the lipid and carbohydrate profile indicators increase the risk of developing a more serious form of the COVID-19 infection, especially among diabetic patients - the latter being more labile. By closely following the dynamics of these markers, we manage to anticipate the severity of the disease, the evolution and the prognosis of the patients. This aspect suggests the need for early diagnosis and represents an advantage in the therapeutic management of patients |
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Cuvinte-cheie lipid metabolism, blood sugar, diabetes, metabolism lipidic, glicemie, diabet zaharat |
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