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SM ISO690:2012 GHEORGHIȚA, Ecaterina, DIUG, Eugen, CIOBANU, Nicolae, GURANDA, Diana, CIOBANU, Cristina, ANTON, Mihai. Gold nanoparticles - vehicles for the targeted transport of drugs. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 489. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 489-489 | ||||||
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Background. Gold nanoparticles (GNp) are an obvious choice for use in medicine due to the possibility of synthesis, stabilization and functionalization, low toxicity and ease of detection. Objective of the study. Description of GNp as nanosystems capable of transporting drug molecules to the site of action. Material and Methods. The main sources of information regarding the structure, methods of production, functionalization, and mechanisms involved in the transport of active substances to the therapeutic target were selected (Scopus, PubMed). Results. Gold nanoparticles have emerged as an excellent candidate for application in the release of various molecules of biologically active substances useful to the target site. For the delivery of useful molecules, GNp requires functionalization such as PEGylation, conjugation of peptides and amino acids, or functionalization with oligonucleotides. Another prerequisite for the effective release of therapeutic agents is the presence of various internal stimuli (glutathione, pH and enzymes) and external stimuli (light, etc.). GNp allow a large amount of drug to be loaded due to its large surface area and versatile surface chemistry. Conclusion. Thus, GNp are a very promising nanosystem in order to improve the bioavailability of various molecules of biologically active substances with a high degree of infiltration into cells. |
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Cuvinte-cheie gold nanoparticles, target transport, Functionalization, therapeutic agents, nanoparticule de aur, transport la țintă, funcționalizare, agenți terapeutici |
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