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SM ISO690:2012 ROTARI, Silvia, DIUG, Eugen, CIOBANU, Nicolae, GURANDA, Diana, CIOBANU, Cristina, ROTARI, Silvia. Polymeric nanoparticles in the treatment of central nervous system diseases. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 488. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 488-488 | ||||||
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Background. The main impediment to the absorption of drugs in the CNS is the blood-brain barrier (BBB). A promising platform in the successful realization of a treatment, are the polymeric nanoparticles (PNP). Objective of the study. Description of PNP as nanosystems capable of transporting drug molecules through BBB at the level of CNS. Material and Methods. The main sources of information regarding the structure, methods of obtaining, functionalization, and mechanisms involved in transporting PNP through BBB to therapeutic target (Scopus, Pubmed). Results. BBB is a mechanical barrier with a very high selective capacity and allows only the entry of water, nutrients, and neurotransmitters that govern the maintenance of the CNS homeostasis. The ability of drugs to cross BBB depends on drug molecule size, hydrophilicity, degree of ionization and controllable use of the drug. After absorption, the polymeric matrix can be triggered to release the drug, resulting in a protected, prolonged, and targeted therapeutic effect. Conclusion. Thus, PNPs are a promising nanosystem in the BBB crossing for an effective treatment of CNS diseases. |
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Cuvinte-cheie central nervous system, blood-brain barrier, polymeric nanoparticles, sistem nervos central, bariera hematoencefalică, nanoparticule polimerice |
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