Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
204 1 |
Ultima descărcare din IBN: 2023-03-15 20:01 |
SM ISO690:2012 STRATAN, Veronica, CHEPTANARU, Eduard, ŢURCANU, Aurel, EFREMOV, Andrei, ONOFREI, Verginia. Our experience in the application of tissue engineering methods in cardiac surgery. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 465. ISSN 2345-1467. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
|
||||||
Pag. 465-465 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
Background: In 2001, a collaboration agreement was signed between the Cardiothoracic and Vascular Surgery Clinic in Hannover, Germany and Nicolae Testemitanu SUMPh Cardiac Surgery Clinic, with the purpose of developing non-immunogenic heart valves based on decellularized valve homographs which could be used in the surgical treatment of congenital heart defects in children and adults. Objective of the study: The analysis and the presentation of the results of the use of decellularized pulmonary homographs (HPD) compared to homographs cryopreserved (HC) and xenograft in cardiac surgery. Material and Methods: This prospective observational study included 121 patients, operated on in the years 2002-2018. Medium age 14.4 years, female 59 (46.8%). The patients were examined by IRM, echocardiography immediately postoperatively, annually until now, studying the data of the ESPOIR project. Results: According to echocardiographic data, the gradient in the preoperative pulmonary valve was 90.5 ± 2.54 mmHg, with values within the limits of the postoperative norm 18.7±2.63 mmHg, and stable evolution over time. In dynamics, the gradient of the pulmonary valve in patients with DPH remains 22.3±1.2 mmHg. In patients with CH, the valvular gradient increases ≥ 50 mmHg and in patients with xenografts ≥ 65 mmHg, with valvular damage at 5-7 years. The degree of pulmonary valve regurgitation is 0.9-1 for patients with HPD and gad 2 -3 for HC and xenografts. Conclusion: In the case of the use of HC and xenografts, the results are limited with complications over time (calcification and restenosis), while HPD have an excellent result over a long period of time (20 years), by adaptive remodeling according to the patient’s age, non-immunogenic and resistant to infections. |
||||||
Cuvinte-cheie decellularized lung homograft, tissue engineering, homogrefă pulmonară decelularizată, inginerie tisulară |
||||||
|