Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
239 1 |
Ultima descărcare din IBN: 2024-01-17 21:27 |
Căutarea după subiecte similare conform CZU |
617ю3-001-02-036-089 (1) |
Științe medicale. Medicină (11143) |
SM ISO690:2012 COȚOBAN, Irina, ARNAUT, Oleg, GRABOVSCHI, Ion. Survival predictictive model for polytrauma patients. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 48. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 617ю3-001-02-036-089 | ||||||
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Rezumat | ||||||
Background. Polytrauma remains a major socio-medical problem with all the characteristics of a silent global pandemic. Components of the protease/antiprotease system (PAS), an active participant in the polytrauma immune response, have shown a predictive potential. Objective of the study. To propose a predictive model for survival probability estimation in polytrauma using PAS components. Material and Methods. In prospective observational research were enrolled 70 polytrauma patients, admitted to IMU IMSP, Chisinau, Republic of Moldova. PAS components were measured in blood plasma (samples collected at 3, 6, 12, 24, 48 and 72 hours after injury), being adjusted for gender, age and ARDS (acute respiratory distress syndrome) development. Results. Using logistic regression technique, a predictive model was elaborated, PAS parameters at 6, 24, and 48 hours after injury being statistically significant. The model’s characteristics as determination (Nagelkerke R Square = 0.804), calibration (Hosmer-Lemeshow test, χ² = 2.498, df = 8, p = 0.962) and discrimination (Sensitivity = 95.7%, Specificity = 84.2%) were acceptable to consider proposed model for validation. Conclusion. In our research, a predictive model based on PAS components was developed. To be implemented in daily clinical practice, the model needs both internal and external validation. |
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Cuvinte-cheie protease/antiprotease system components, predictive model, polytrauma, componente ale sistemului proteaze/antiproteaze, model predictiv, politraumatism |
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