The evidence suggests the use of a biopsychosocial approach for the assessment and management of people with chronic musculoskeletal pain to best capture the multidimensional aspects of pain. A biopsychosocial approach can inform a tailored approach to the management of chronic musculoskeletal pain. This presentation will discuss the assessment of the multiple domains of chronic musculoskeletal pain, including sensory and affective qualities, temporal dimensions, location and distribution of pain using valid and reliable methods. Assessment of chronic musculoskeletal pain will also include identification of the different pain mechanisms that may contribute to the generation and maintenance of chronic musculoskeletal pain within the context of the biopsychosocial model. The evidence for best practice care and clinical guidelines for chronic MSK pain will be discussed, including physical activity and exercise-based interventions.