Aim: Increased prevalence of autoantibodies has been suggested in patients with epilepsy. The effectiveness of immunomodulatory treatments in cases with childhood epilepsies sugest the role of immune mechanisms in the pathogenesis of this   desease. The purpose of this study was to determine   antiphospholipid antibodies (aPLs, immunoglobulin G class), in children  with epilepsy. Methods: we studied 60 children (34 boys and 26 girls) with a mean age of 2,1 years (range 0.1–4,2 years).The control group consist of 70 healthy subjects, mean age was 2,4 years.  The mean age of onset of epilepsy was 1,2 years (range 0,2 -2,2). None of the children had any clinical signs of immune system disorders. The type of epilepsy was partial in 42 patients, primary general- ized in 13 cases and unclassified in 5 patients. Results: In the study group, there were higher num- ber (16cases) of aPLs  immunoglobulin G class posi- tive  subjects  (26,6%)  compared  with  controls  (4cas- es-5,7%) (P=0,011). These antibodies were   common (77–84%) in children with multiple seizure types as- sociated often with symptomatic etiology, early onset and high frequency of seizures. Conclusion: Even though the significance of these au- toantibodies remains unknown, their increased preva- lence indicates that immune system mediated mecha- nisms may have a role in the manifestation of epilepsy in some children, especially in the subgroups of earlyure-frequency,  therapy-resistant  epi- s with multiple seizure types.