Background: Hematopoietic system involvement in systemic lupus erythematosus (SLE) remains in the focus of specialists and until nowerdays. Hematological manifestations are frequently seen in SLE - anaemia, leucopenia and thrombocytopenia which may result firstly from bone marrow failure or excessive peripheral cell destruction, both of which may be immune mediated. The most common forms of anaemia, described in the modern trials are iron-deficiency anaemia (IDA), anaemia of chronic disease (ACD), autoimmune hemolytic anemia (AHA), drug-induced myelotoxicity, anaemia of chronic renal failure and rarely types such as pure red cell aplasia, B12 deficiency anemia and myelofibrosis. The aim: To study the frequency of haematological disorders in Moldova Lupus Cohort. Material and methods: We examined 59 patients with anemia out of 86 patients with SLE that were included in our study group. Blood and standard immunological tests were evaluated, erythropoietin (Epo) and ferritin levels were evaluated by ELISA method. Anti DNA-ds antibodies, erythropoietin and ferritin levels were measured at baseline. Disease activity was assessed by Systemic Lupus Activity Measure (SLAM). Results: Anaemia was more common manifestation. After the investigations we determined the following forms of anemia: the anemia of chronic disease (ACD) n = 34 (57.6%), iron deficiency anemia (IDA) n = 20 (33.9%), autoimmune hemolytic anemia (AHA) n = 3 (5.1%) and other forms such as anaemia of chronic renal failure (ACRF) n = 2 (3.4%). Leucopenia was present at 18 (30.5%) patients, limphopenia at 19 (32.2%) patients and thrombocitopenia at 13 (22.0%) patients. Assessment of disease activity by SLAM showed that low disease activity was determined in 12 (20.3%) patients, moderate activity was found in 36 (61.0%) and high activity - in only 11 (18.6%) patients. This demonstrated that in examined patients was predominant moderate activity 61.0% cases and ACD 57.6%. Discussions. SLE is considered to be a disease with multiform clinical and biological manifestations – with a poor prognosis and unpredictable evolution untreated and undiagnosed cases in time. However, this pathology by its ethiopathogenesis, incomplete attention and poliorganic involvement has usually a fatal outcome. Although anemia is one of the most common features of SLE, most studies are devoted to hemolytic anaemia. There is a novelty that not only the haemolytic anaemia develops in SLE, but it may evolve as an independent disease. Conclusions. Hematologic involvement is included in the diagnostic criteria of systemic lupus erythematosus, anemia being a common manifestation in these patients. Anemia is a common manifestation of systemic lupus erythematosus and can be detected by simple laboratory tests - hemoglobin, hematocrit and number of erythrocytes. Anemia is associated with some clinical manifestations, especially with renal and neuropsychiatric and with high activity in lupus. Anemia of chronic disease was characterized by normal iron and ferritine, and low erythropoietin levels. Irondeficient anemia was presented by high erythropoietin levels and low ferritin levels.