Introduction: Ovarian hyperstimulation syndrome (OHSS) usually occurs as a result of taking hormonal medications that stimulate the development of eggs in a woman’s ovaries. In most cases, the symptoms of OHSS begin within 10 days after you take medications to stimulate ovulation. The severity of OHSS symptoms varies, and symptoms may worsen or improve over time, and include mild to moderate abdominal pain, bloating, nausea and vomiting, decreased urinary frequency, dark urine, dizziness and other. Changes in bio-chemical composition of blood are not infrequent. Objective: Analysis of OHSS cases at Mother and Child Institute PMSI (IM şi C) during the last four years. Materials and Methods: A total of 32 cases of OHSS were indentified and analyzed. Average age was 27.6±0,8 years (range 24 - 31). Diagnosis was obtained and confirmed using both clinical manifestations as well as laboratory and ultrasonografic investigations. Results: In 75% (n=24) of cases an early onset of OHSS has been observed, while the rest of 25% (n=8) symptoms were delayed. Grade II ovarian hyperstimulation was seen in 62.5% (n=20) with the rest of the patients exhibiting a Grade III stage disease. All patients reported abdominal pain, bloating was reported by 78.1% (n=25) of patients. The following symptoms were observed: nausea 34.3% (n=11), mouth dryness 46.8% (n=15), and oliguria 56.2% (n=18). Lab test results (i.e. AlAT, AsAT, Hyperbilirubinemia, other) indicating hepatic changes were seen in 46.8 (n=15) of patients. Ultra-sonographic evaluation indicated an average increase in ovarian size to 105.3±1.4 x 98±1.2 mm (range 64 x 63 мм - 120 x 115 mm). Excessive free fluid in the abdominal cavity was seen in 100% of cases, in pleural cavity in 43.8% (n=14) and in the pericardial cavity in 3.3% (n=3) of cases. Abdominal compartment syndrome was observed in 37.5% (n=12) of cases, which mandated laparocenthesis, four of these patients also necessitated thoracocethesis. 43.2% (n=14) of cases were grave enough to requite management in conditions of an ICU. Conclusions: Ovarian hyperstimulation syndrome is encountered rather often and may pose a significant risk during ovarian stimulation. Such patients require careful medical, laboratory and diagnostic evaluation and management. Advanced staged of the disease require hospitalization and management in specialized units.