After the COVID-19 outbreak being declared as a pandemic by the World Health Organization (WHO), the measures that were taken in order to control the infection have become more than just preventive measures; they have turned into measures that have changed people’s whole lifestyle at a global level. Therefore, the amplitude and the effects of the pandemic required extraordinary measures, both in terms of medical (public health) and in terms of social behavior of the individual. It has become obvious that, in order to successfully control and stop the pandemic, efforts are needed not only at the level of the individual and small social groups, but as a society. Unfortunately, it was proved that all these control measures had directly affected the mental health, overlapping with those generated by the pandemic itself. In this special context, since having at hand data about the amplification of the suicidal phenomenon during the pandemic, it became very clear that to the epidemiological and social control measures solid mental health promotion and suicide prevention interventions on both vulnerable groups (e.g. individuals with mental disorders history) and the wider community are needed. In order to be successful, this approach needs a solid background of the scientific data as well as the work of multidisciplinary research teams that could cover the whole range of the psycho-social environment.