Some metabolic aspects of the izoturone and diazepam association interaction with hyperbaric oxygen In the experiments on rats the aspects of the izoturone and diazepam association interaction with hyperbaric oxygen (HBO) on the lipid metabolism level was studied. HBO (6 ata 50 min) caused the increase of plasmatic concentration of total lipids, total phospholipids, total cholesterol, esterified cholesterol, fatty nonesterified acids, total lipoproteins, α γ- lipoproteins, β-lipoproteins, cholesterol of lipoproteins. Association of the izoturone (20 mg/kg) and diazepam (5 mg/kg) in normobaric conditions provoked the decrease of the content of esterified cholesterol and the increase of total phospholipids. A complex metabolic interaction of the level of lipidic and lipoproteinic metabolism on the simultaneous prescription of izoturone and diazepam combination and HBO was revealed. In some of cases the association of izoturone and diazepam and HBO reciprocally normalized the modification of parameters of lipidic metabolism, in other pharmacological agents act similarly manifasting a tendency of effects accumulation.

În experimente pe şobolani au fost studiate aspectele metabolice ale interacţiunii asocierii izoturon şi diazepam cu oxigenul hiperbaric (OHB) la nivelul metabolismului lipidic. OHB (6 ata 50 min) a cauzat majorarea concentraţiei plasmatice de lipide totale, fosfolipide totale, colesterol total, colesterol esterificat, acizi graşi neesterificaţi, lipoproteine totale, α γ- lipoproteine, β-lipoproteine, colesterol al lipoproteinelor. Asocierea izoturonului (20 mg/kg) şi diazepamului (5 mg/kg) în condiţii normobarice a micşorat concentraţia plasmatică de colesterol esterificat şi a majorat de fosfolipide totale. La administrarea concomitentă a asocierii izoturonului şi diazepamului cu OHB s-a observat o interacţiune complexă la nivelul metabolismului lipidic şi lipoproteic. În unele cazuri combinaţia şi OHB normalizează reciproc modificările indicilor metabolismului lipidic, în altele – agenţii farmacologici acţionează similar, manifestând tendinţă de acumulare a efectelor.